Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging ‘fuel’ through an alternative supply route, called macropinocytosis. Blocking this process, often described as ‘cellular drinking,’ could lead to tumor-starving drugs. Now, scientists have identified a signaling pathway that regulates macropinocytosis, the nutritional cue that triggers the process and key metabolic differences between tumors — revealing new directions for drug development and patient treatment.
Nutritional cues regulate pancreatic tumor’s ‘cell drinking’
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